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Medicine Grade immune booster medicines phloridzin in bulk stock
Product Details
Product name:Apple peel extract
Extract source:Malus pumila Mill.
Specification:98%
Active ingredient: Phloridzin
Used Part:peel
CAS NO. : 60-81-1
Molecular formula C15H14O5
Molecular weight:274.27
Appearance:white Powder
Flavor: Characteristic taste
Particle Size:80% pass through 80 mesh sieve
Test mothed: HPLC
Extract Solvent: Ethanol & Water
Solubility: Soluble in water, ethanol
Usage: Pharmaceuticals, healthcares,and cosmetics
Product Description
Phloridzin is the specific and competitive inhibition of
sodium/glucose cotransporters in the intestine (SGLT1) and kidney
(SGLT2). This property which could be useful in the management of
postprandial hyperglycemia in diabetes and related disorders.
Phloridzin is one of the dihydrochalcones typically contained in
apples and in apple-derived products. The effect of phloridzin
orally doses 5, 10, 20 and 40 mg/kg body weight on diabetes was
tested in a streptozotocin-induced rat model of diabetes type 1.
From beneficial effect of this compound is significant reduction of
blood glucose levels and improve dyslipidemia in diabetic rats. As
a well-known consequence of becoming diabetic, urine volume and
water intake were significantly increased. Administration of
phloridzin reduced urine volume and water intake in a
dose-dependent manner. Phloretin decreases of food consumption, as
well as a marked lowering in the weight. In conclusion, this
compound could be proposed as an antihyperglycemic and
antihyperlipidemic agent in diabetes and potential therapeutic in
obesity
Product Analysis
Item | Specification | Result | Method |
BasicProduct Information | |||
Product name | phloridzin | ||
Part of the Plant | peel | Conform | / |
Country of Origin | China | Conform | / |
Organoleptic Data | |||
Appearance | Fine powder | Conform | NLS-QCS-1008 |
Color | white powder | Conform | GB/T 5492-2008 |
Odor& Taste | Characteristic | Conform | GB/T 5492-2008 |
Process Data | |||
Solvent(s) Used | Water and ethyl alcohol | Conform | / |
Extract ration | / | Conform | |
Content | Paeoniflorin≥98% | 98.18 | |
Drying Method | Spray drying | Conform | / |
Excipient | Maltodextrin | Conform | / |
Physical Characteristics | |||
Particle Size (80 mesh) | 98.0%pass 80mesh | Conform | GB/T 5507-2008 |
Moisture | <5.0% | 2.8% | GB/T 14769-1993 |
Ash Content | <4.0% | 1.4% | AOAC 942.05, 18th |
Solvent Residue | Eur. Pharm | Conform | NLS-QCS-1007 |
Heavy Metals | |||
Total Heavy Metals | <10 ppm | Conform | USP <231>, method II |
Arsenic | <1.0 ppm | Conform | AOAC 986.15, 18th |
Lead | <1.0 ppm | Conform | AOAC 986.15, 18th |
Mercury | <0.5 ppm | Conform | AOAC 971.21, 18th |
Pesticide Residue | |||
666 | <0.2ppm | Conform | GB/T5009.19-1996 |
DDT | <0.2ppm | Conform | GB/T5009.19-1996 |
Microbiology | |||
Total Plate Count | <1,000cfu/g | 17cfu/g | AOAC 990.12, 18th |
Total Yeast & Mold | <100cfu/g | 3cfu/g | FDA (BAM) Chapter 18, 8th Ed. |
E. Coli | Negative | Negative | AOAC 997.11, 18th |
Salmonella | Negative | Negative | FDA (BAM) Chapter 5, 8th Ed. |
Product Function
1.Phloridzin can be used to treat diabetes. It can inhibit the
renal proximal tubule reabsorption of glucose, urinary glucose
excretion increased, thereby reducing the level of blood glucose
and serum insulin levels are not affected
2.Phloridzin can be used to whitening and acne treatment. Phlorizin
can prevent the entry of glucose into epidermal cells, thereby
slowing the secretion of sebum to help prevent the occurrence of
acne. Tyrosinase is the major rate-limiting enzyme of the melanin
biosynthesis, phlorizin through to inhibit tyrosinase to achieve
whitening
3.Reduce the number of atherosclerotic lesions in arteries, the
amount of cholesterol produced in the liver and uric acid content
in the blood
4.Slow the growth of cancer cells and tumors and promote cancer
cell death. Prevent skin, breast and colon cancer, and lower the
risk of colon and lung cancer; Effect against external aging by
promoting the health of skin cells and rejuvenation. Effect the
Internal aging by promoting organ health, destroying the free
radicals and strengthening fibers;