CLIA Glutamic Acid Decarboxylase Antibody IVD Products Chemiluminescent Immunoassay In DIABETES

Glutamic Acid Decarboxylase Antibody In Vitro Diagnostic Reagents (chemiluminescent immunoassay)) in DIABETES

Clinical significance of GAD65 in diabetes

The positive rate of GAD65 in new-onset T1DM patients is about 80%, and the antibody level is relatively stable, with a sustainable high titer for more than 10 years. Adult late-onset autoimmune diabetes mellitus (LADA) with a history of T1DM adult type, treatment independent of insulin, clinical manifestations similar to type 2 diabetes mellitus (T2DM), difficult to differential diagnosis, GAD65 is currently recognized as an immunological indicator for the diagnosis of LADA. Compared with other antibodies, GAD65 has the characteristics of good correlation with the slow injury of B cells, early appearance, long duration, large age span, high positive rate, and easy standardization of detection, which can well predict B cell function.

Clinical significance of GAD65 antibody in other diseases

GAD65 can be detected in the serum of 60%-80% of patients with stiff man syndrome (SMS). The detection of anti-GAD antibodies in the cerebrospinal fluid of SMS patients was more specific. GAD65 can also be detected when T1DM occurs in patients with autoimmune polyglandular syndrome (APS). Many studies have shown that anti-GAD antibodies can damage the structure and function of pancreatic islet B cells, resulting in insulin deficiency and participating in the pathogenesis of T1DM. Regardless of whether it is T1DM or T2DM, GAD65 positive indicates endogenous insulin deficiency and requires insulin therapy in the future.

Zecen Biotech CO., LTD., founded in 2011, is a leading Chinese diagnostics manufacturer specializing in in-vitro diagnostics devices and reagents. Zecen focus on the Chemiluminescent immunoassay (CLIA) field. With all products CE marked, our market presence currently spreads from across China to other countries including India, Switzerland, Russia etc., Zecen is expanding its footprint to become a global brand.

Zecen is the only enterprise with independent intellectual property rights in the entire chemiluminescence industry chain in China, including reagent, instrument, magnetic microbead, and reagent raw material. Our current products include more than 100 assays, from thyroid, inflammation, diabetes, tumer markers, immune disorders, hormones to cardiac markers. Our ever-expanding test menu helps our customers and collaborators keep up with the demands of healthcare sector. Zecen is striving for innovation and perfection to deliver the best products to the customers.

As a manufacturer, Zecen provide the OEM, ODM and other customized service of all products. We have the core R&D centers and innovative ability to lay a solid foundation for developing the broadest range of CLIA analyzers and test menu. High-quality sales and after-sales links provide the more intimate service. The patent and CE certification give us the confident sending all over the world, and more than 50 companys in the requiement of customized and have a long term coorperation with Zecen.