Keypath P16 Protein Marker ICC Immunoassay Test Kit Cervical Cancer Screening
Brand Name:KISSH
Certification:CE
Model Number:K104
Minimum Order Quantity:Negotiable
Delivery Time:3 days
Payment Terms:T/T
Contact Now
Add to Cart
Active Member
Location:
Shenzhen China
Address:
301,Building B1,Compass Life Science Industrial Park, Julongshan Road A, Pingshan District, Shenzhen,China
Supplier`s last login times:
within 1 hours
Product Details
Company Profile
Product Details
Keypath p16 Immunoassay Test Kit(ICC)
Introduction
p16 Antibody Reagent is an important marker for cervical cancer screening and diagnosis.
The p16INK4a detection technology is a new detection method joint recommended by CAP and ASCCP.
There’s close relationship between p16 and cervical cancer.
Persistent HPV infection produces viral oncogenic protein E7, which binds to host cell PRB, releases transcription factor E2F, interferes with the cell cycle, and causes cells to continue to differentiate and develop precancerous lesions.
Principle
Based on the principle of specific binding between immunological
antigen and antibody, the antibody is combined with enzyme-labeled
chromogenic system to form a complex, and enzyme substrate
(chromogenic agent) is added to make it chromogenic to locate and
characterize the antigen to be detected. The location of cell
staining is nucleus/cytoplasm.
P16 is one of the cell cycle regulatory proteins, also known as
"mitosis inhibitor". Its role is to competitively bind CDK4/6 with
cyclin D, and stop
the process of cells from G1 to S, thus negatively regulating
mitosis. In tumor cells, gene mutation or deletion often leads to
the increase of p16
expression, but the cell cycle can not be regulated. This antibody
is mainly used in tumor research.
Advantages
- The detection is with statistical significance by improved sensitivity and specificity.
- Reduce workload, improve image reading efficiency, and reduce missed diagnosis rate.
- Reduce referral rates for colposcopy and reduce overtreatment.
- Whether p16 staining is positive or not indicates transient or persistent HPV infection, and p16-positive cells prompt the cytology doctor to review the liquid-based results.
Packaging
- 25 tests/kit ,50 tests/kit ,100 tests/kit
Keypath P16 Protein Marker ICC Immunoassay Test Kit Cervical Cancer Screening
Inquiry Cart
0